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Proteins that are involved in breaking down muscle are downregulated, meaning less of them are made. In contrast, a substance called glutamine can be made from a cell. Glutamine also promotes protein synthesis in the body. But how to synthesise glutamine in our bodies? The process of glutamine production is controlled and directed by two genes - PLCGRP and GABAAATACC. PLCGRP is a transcription factor that plays a role in glutamine production. GABAAATACC is a gene whose activity is regulated by the GNA protein. How do we make glutamine and how can it help heal? Glutamine is a necessary amino acid, which is necessary for life. So it can be used in our bodies in an essential role – for cell repair, for repairing damage, for maintaining an adequate supply of energy, for making growth hormone, for building bones and teeth, for fighting infection. Glutamine is also important in the synthesis of two vital proteins, TGF-α and BMP-2. TGF-α is a protein which helps to stimulate the growth and repair of cells. BMP-2 is a protein which promotes the maturation of certain cells in the body. But there are many other roles for glutamine. It also helps to keep us healthy. So one of the ways that glutamine can help to heal damage in the body is by helping cells to regenerate. As I have described before, cells produce glutamine after injury or injury-related damage. And one way for cells to regenerate is by using the glutamine that is formed. This means that if a cell is injured, one of the first steps is to start making glutamine. This is essential as cells are not made up solely of protein alone. But when the body does not have enough glutamine to repair its cells it will be made from other, inactive substances. The body's immune system, for example, releases many compounds that can interfere with normal cell repair, so it is best to be able to recognise these and to repair damaged cells with the glutamine that is normally formed. Can glutamine help prevent or treat asthma? Glutamine may also help prevent or treat asthma. Asthma affects up to one in every 10,000 children. This means that about one in five children in Britain suffer from seasonal or chronic wheezing. Glutamine may help to prevent wheeze and helps to stop the lungs developing abnormally as a result. Related Article:
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