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Neither of the two trials comparing steroid spray to placebo spray in adults showed a benefit of steroids across a range of different measuresof acne severity. The studies also included a randomised, controlled, placebo-controlled trial comparing corticosteroids across five different acne severity grades, from 'very mild' to 'severe'. Results for the first study showed that a 6-month course of corticosteroid in adults with moderate-to-severe acne showed a 12% benefit over placebo , whereas for the secondary study, the benefit was 12% , hgh supplement walmart. The reason this finding was not replicated in the first study and not replicated in the second is that the outcome measure used in the first study had not been validated for acne severity , hgh supplement powder. A recent meta-analysis has found a small positive impact of steroids on acne severity in adults using a validated measure of acne, the International Acne Severity Score , hgh supplement cost. A third study compared the efficacy of three types of acne treatments – a steroid spray, minoxidil and topical medication – in a randomized controlled trial of adult patients with moderate-to-severe acne. These include those who have experienced a history of significant acne before treatment, are well informed and who have used acne cream previously and have been free from other acne treatment in the time before baseline , hgh supplement spray. This study also employed the 'classic' method of scoring patients' acne severity, based on five dermatological categories which is well validated and has been used widely in clinical practice , spray hgh. This study found that there was a significant benefit in reducing inflammation, with a 6-month regimen of minoxidil being more effective than the placebo arm, and a 10-month regimen of minoxidil being superior to the placebo . Results from this study support the hypothesis that treatments can reduce inflammation in adults with moderate-to-severe acne, hgh supplement dangers. A further trial comparing the efficacy of isotretinoin (Accutane) to placebo in adults with moderate-to-severe acne found no benefit of isotretinoin over placebo at 10 weeks, but a modest benefit at 12 weeks . However, patients treated with isotretinoin showed a significant reduction in inflammatory lesions after 6 months of treatment compared to controls , hgh spray. In addition to these well-designed studies of adults, there are also many older population studies of adults with moderate-to-severe acne that show little or no benefit of treatment, and many other studies comparing steroid products in adults with moderate-to-severe acne.
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